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COVID-19 Testing

Testing for COVID-19 is crucial to understand who is infected and therefore a risk to others by spreading the infection.

Number of people tested

2038

2038 people were tested between 1 to 99 times

261 staff
1777 Volunteers

Number of Tests

16089

PCR Tests

6150

Antibody Tests

View all current up to date test results

We perform polymerase chain reaction (PCR) and microscopic holographic imaging tests repeatedly, at least every two days for staff or when a visitor attends the clinic. We have also continued to test for antibodies. By repeating these tests over time, we can establish how long the antibodies take to develop and how long immunity may last in each person.

This page provides a summary of our COVID-19 testing results, further details can be accessed by using the buttons shown below.

COVID-19 Test Results

PCR Test results

% Staff Positive Test Results

Staff | Average Age: 34 Years

8447 Negative
79 Positive (47 individuals, some testing positive multiple times)
Number of cases testing positive for the first time

Demographics

53%
Female
47%
Male

Visitors & Volunteers | Average Age: 40 Years

5880 Negative
53 Positive (23 individuals, some testing positive multiple times)
Number of cases testing positive for the first time

Demographics

35%
Female
65%
Male

Antibody Test results

Staff | Average Age: 34 Years

207 IgG Positive only
31 IgM Postive only
173 IgM Positive and IgG Positive
2395 Negative
Number of cases testing positive for the first time
From week 26 antibody test frequency reduced to every 3 months

Visitors & Volunteers | Average Age: 40 Years

181 IgG Positive only
33 IgM Positive only
153 IgM Positive and IgG Positive
2951 Negative
Number of cases testing positive for the first time

Antibody levels over time

For each individual where their antibody levels have been measured more than once their series of results (dots) over time are connected by a coloured line. There is a clear decline in antibody levels overtime. The rate of decline suggests that after four months post infection detectable levels of antibodies are likely to be low.

One individual (orange line) shows a significant change at 171 days with detectable antibodies appearing for the first time, this is probably due to reinfection as 5 months after testing positive for COVID-19 by PCR for the first time, and subsequent negative PCR test results, the individual tested positive again by PCR.

The graphs above show that the number of weekly tests has decreased in recent weeks. This is due to Richmond Research Institute's ongoing commitment to ensure staff safety by increasing home working measures... Read more

Furthermore, travel restrictions imposed by the government mean that fewer volunteers were able to access the unit for testing. As these restrictions continue to be reviewed and will likely be loosened over the coming weeks, we aim to boost testing for COVID-19 again shortly.

Summary of Results

The UK is experiencing a surge in new coronavirus infections, with daily cases at record level. Understandably we have also detected an increase in positive cases. Over the past eight weeks six new cases among staff  have been recorded.  

The graphs above show that since March 2020 out of 261 members of staff at the clinical trials unit, 47 tested positive for COVID-19 by PCR and 51 have produced antibodies. For those testing positive for SARS-CoV-2 antibodies we have measured a decline in their antibody level over time.

We have detected a probable case of reinfection, where 5 months after testing positive for COVID-19 by PCR for the first time, and subsequent negative PCR test results, the individual has tested positive again by PCR.  Of note is the relatively high level of antibodies detected for this individual 19 days post their recent positive PCR test, whereas after their first positive PCR test they did not develop detectable antibody levels. Worldwide cases of reinfections are being reported with increasing frequency although are currently considered rare8,9,10.

Our recent publication ‘Why the SARS-CoV-2 antibody test results may be misleading: insights from a longitudinal analysis of COVID-19’ shows our results align with the study led by Imperial College reporting  antibodies levels decline significantly over four months post infection4,5,6,7.

Updated on 13th January 2021

Overview of the COVID-19 tests

Four tests are being conducted: a Polymerase Chain Reaction (PCR) test, a COVID-19 Rapid Antibody Test, a Chemiluminescent Microparticle Immunoassay (CMIA) test, and a new microscopic holographic imaging and artificial intelligence (AI) software technology.

By using different tests, we can determine whether a person is currently infected with the COVID-19 virus or if they previously had the virus. This is important because many people may not develop any symptoms after becoming infected and thus may not be aware that they are spreading the virus.

View more info about each test using the plus symbols below:

Polymerase Chain Reaction (PCR)

The PCR test is currently a gold standard to check for COVID-19 infections. It measures whether SARS-CoV-2 genetic material is present in a person’s system. At Richmond Research Institute, we take throat swab samples and can produce PCR test results within just 20 minutes.

We are using the Menarini Fast Point-of-care RT-PCR test. For positive cases, we also send a sample to be verified by an independent laboratory. This allows us to check for false positive results.

Rapid Antibody Test

The COVID-19 Rapid Antibody test, known as the RAPG-COV-019 kit by Biopanda, indicates whether someone has had the SARS-CoV-2 virus and is potentially immune. It measures Immunoglobulin G (IgG) and Immunoglobulin M (IgM) - antibodies produced by the body as it fights the virus.

Usually, it takes five to 10 days for these antibodies to become measurable in blood. Over time, IgM levels will drop, while IgG levels will increase and peak at around 30 days. This allows us to measure if people had a corona virus infection. The challenge with these tests is that they are not sensitive or specific; therefore, another corona virus infection may cause a positive test result.

By using the RAPG-COV-019 antibody test kit on finger prick blood samples we can generate results within 10 minutes.

Chemiluminescent Microparticle Immunoassay (CMIA)

We are also using another antibody test where we can measure the levels of antibodies to see how these change over time. The Abbott Laboratories chemiluminescent microparticle immunoassay (CMIA) works by binding to SARS-CoV-2-specific IgG antibodies in a blood sample. Upon binding to IgG, a luminescent signal is generated, which can be measured and is directly proportional to the concentration of SARS-CoV-2-specific IgG antibodies.

Richmond Research Institute is continuously evaluating new test methods that produce fast and accurate results.

Microscopic Holographic Imaging

The Virolens system was developed in response to surging demand for rapid COVID-19 screening devices. It is a microscopic holographic imaging and AI software technology. The Virolens system works by using a digital camera that is attached to a microscope to analyse saliva samples. The data obtained from a sample is then run through a computer system that is trained by AI to identify the unique pattern of the virus from other cells. A result is available in only 20 seconds.

Continuous Development

We continue to actively source new point of care tests which are simple, fast, and can be administered frequently. The ability to identify infectious individuals quickly is essential to ensure normality is restored.

Study Background

Working with our partner organisation, Richmond Pharmacology Limited (RPL), the initial emphasis of our COVID-19 response was on staff, clinical trial volunteers, and visitor safety.

At RPL’s London Bridge clinical trial facility which we use for our studies, RPL acted quickly and responsibly to mitigate the risks, implementing strict entry control measures for access to the research unit, evaluating key indicators such as symptom scores, body temperature, travel history, and contact tracing for anyone entering the building. The wearing of masks inside the research unit is mandatory and the number of people on site is limited to enable social distancing.

The testing regime is key as it is well-known that COVID-19 can be transmitted by asymptomatic carriers
1

References:

  1. National Center for Biotechnology Information
  2. The Lancet: Peer Reviewed Journal
  3. JAMA Network: Open Access Medical Journal
  4. Covid.joinzoe: COVID Symptom Study
  5. GOV.UK: Coronavirus (COVID-19) in the UK
  6. COVID-19 Surveillance Report
  7. Why the SARS-CoV-2 antibody test results may be misleading: insights from a longitudinal analysis of COVID-19
  8. Reinfection with SARS-CoV-2: Implications for Vaccines
  9. SARS-CoV-2 reinfection and implications for vaccine development
  10. COVID reinfections are unusual — but could still help the virus to spread
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