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Research

The Richmond Research Institute is an independent, not-for-profit, academic research unit dedicated to clinical trial safety optimisation. Our studies help to improve the health and safety of patients taking part in clinical trials.

Controlled trials

DIabetes health

We investigate the health effects of interventions.

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Cohort studies

DIabetes health

We perform studies on defined clinical groups.

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Big data analytical studies

American heart association

We gather information from large datasets to obtain health-related insights.

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Controlled trials

Current studies

12.061: Type I diabetes monitoring and QTc interval.

Diabetes mellitus (DM) is a common metabolic disorder characterised by high blood glucose. It is caused by a lack of pancreatic beta-cell insulin production in type 1 DM. Patients with type 1 diabetes mellitus have a seven-fold higher risk of sudden cardiac death than age-matched nondiabetic controls, although the underlying mechanism for this is unclear. Sudden cardiac death is closely linked with cardiac arrhythmia, particularly Torsades de Points (TdP) and prolongation of the QT interval is a key risk factor.

20.032: Type II diabetes monitoring and QTc interval.

Diabetes mellitus (DM) is a common metabolic disorder characterised by high blood glucose. It is caused by a reduced sensitivity of tissues to insulin in type 2 DM. Patients with type 2 diabetes mellitus may be at an increased risk of sudden cardiac death, hence this study. Sudden cardiac death is closely linked with cardiac arrhythmia, particularly Torsades de Points (TdP) and prolongation of the QT interval is a key risk factor.

21.026: Telemonitoring in cardiac amyloidosis (PATHWAY-RCT).

Cardiac amyloidosis is a condition where the heart muscle, amongst other tissues, is infiltrated by the abnormal build-up of proteins called amyloid. This stiffens and thickens the heart muscle over time which makes it less efficient and puts further stress and strain on the other chambers of the heart, leading to heart failure. Telemonitoring is the practice of monitoring patients from a distance and has been shown to reduce heart failure admissions and death in patients with heart failure from any cause. This prospective clinical study monitors the weight, the most reliable clinical sign of this fluid build-up, of patients with cardiac amyloidosis at home and intervene where a build-up of fluid is observed by telephone discussion with a doctor. This study will evaluate the effect fairly by comparing telemonitoring with usual care.

Controlled Trials Publications

Considering the risk of QTc prolongation in patients with diabetes mellitus

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Effect of hyperglycaemia in combination with moxifloxacin on cardiac repolarization in male and female patients with type I diabetes

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Confirmation of the cardiac safety of nolasiban in a randomised cohort of healthy female volunteers

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Comparing the consistency of electrocardiogram interval measurements by resting ECG versus 12-lead Holter

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A Phase 1 Study to Investigate the Effects of Cortexolone 17α-Propionate, Also Known as Clascoterone, on the QT Interval Using the Meal Effect to Demonstrate ECG Assay Sensitivity

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Effects of progesterone and estradiol on QT subintervals over the course of a menstrual cycle

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Do hERG blocking agents further increase the risk of sudden cardiac death in patients with type 1 diabetes?

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Cohort studies

Current studies

19.030: Developing a non-invasive clinical tool to predict Non-Alcoholic Fatty Liver Disease (NAFLD) in clinical trial volunteers. 

NAFLD is a very common (25% of adults worldwide) and varied condition ranging from no symptoms to inflammation, scarring and cancer. In clinical trials it is important to detect fatty liver. Patients taking new medicines are monitored closely and carefully for the presence of any side-effects. Liver drug reactions are the 2nd most common reason for stopping a trial. Fatty liver can confuse or worsen a drug reaction, so being able to detect this condition makes trials safer and more effective. The development of an artificial intelligence prediction tool is the focus of this study.

Cohort Studies Publications

Kinetics of anti-SARS-CoV-2 IgG antibody levels and potential influential factors in subjects with COVID-19: A 11-month follow-up study

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Race and diurnal variability of biomarkers for diabetes and cardiovascular disease

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Big data analytical studies

Current studies

22.015: Longitudinal Food Effects (LIFE) study. 

Traditional approaches to understanding the effects of diet on health are performed in large observational cohorts followed up over decades. These study designs have several well-recognised flaws including expense, recall and survey bias, an inability to track food changes over time, and an inability to track important confounders, such as the food habits of co-habitants. Supermarket loyalty schemes offer a new source of historical and highly accurate purchasing habits for individuals. This large-scale study with consenting individuals who download their data and correlate this with a health questionnaire, will enable the development of an effective database of health-food outcomes.

Big Data Analytical Studies Publications

Cardiovascular risk factor insights into the tesco 1.0 dataset

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We work with partners at the following organisations: 

richmond research institute

We have a track record in conducting clinical research.

Publications

We present our scientific findings at meetings.

Videos

Our academic research helps improve lives and strengthens scientific insights.

Research

COVID-19 Testing

DIabetes health

We are studying long term immunity of individuals who have contracted COVID-19.

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Cardiac Health

DIabetes health

We are investigating how drugs affect the cardiovascular system of healthy and diseased patient populations.

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Clinical Trial Design & Methodology

American heart association

We examine methods and technological innovations to improve the design of clinical trials.

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Hepatology

Hepatology

We identify predictive factors for hepatic steatosis in clinical trial volunteers to help improve volunteer screening and mitigate the risks of confounding variables impacting the quality of trial data and results.

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Ethnic and Sex Differences in Physiology & Drug Responses

Ethnic differences in biomarkers

We study how individual ethnic and sex differences can affect cardiac safety assessments and biomarker analyses.

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Greetings, Exalted One. Allow me to introduce myself. I am Luke Skywalker, Jedi Knight and friend to Captain Solo. I know that you are powerful, mighty Jabba, and that your anger with Solo must be equally powerful. I seek an audience with Your Greatness to bargain for Solo's life. With your wisdom, I'm sure that we can work out an arrangement which will be mutually beneficial and enable us to avoid any unpleasant confrontation.
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Greetings, Exalted One. Allow me to introduce myself. I am Luke Skywalker, Jedi Knight and friend to Captain Solo. I know that you are powerful, mighty Jabba, and that your anger with Solo must be equally powerful. I seek an audience with Your Greatness to bargain for Solo's life. With your wisdom, I'm sure that we can work out an arrangement which will be mutually beneficial and enable us to avoid any unpleasant confrontation.
Will I be able to upgrade down the road?
Greetings, Exalted One. Allow me to introduce myself. I am Luke Skywalker, Jedi Knight and friend to Captain Solo. I know that you are powerful, mighty Jabba, and that your anger with Solo must be equally powerful. I seek an audience with Your Greatness to bargain for Solo's life. With your wisdom, I'm sure that we can work out an arrangement which will be mutually beneficial and enable us to avoid any unpleasant confrontation.
What's the difference between the Pro plans?
Greetings, Exalted One. Allow me to introduce myself. I am Luke Skywalker, Jedi Knight and friend to Captain Solo. I know that you are powerful, mighty Jabba, and that your anger with Solo must be equally powerful. I seek an audience with Your Greatness to bargain for Solo's life. With your wisdom, I'm sure that we can work out an arrangement which will be mutually beneficial and enable us to avoid any unpleasant confrontation.
Can I cancel my membership at anytime?
Greetings, Exalted One. Allow me to introduce myself. I am Luke Skywalker, Jedi Knight and friend to Captain Solo. I know that you are powerful, mighty Jabba, and that your anger with Solo must be equally powerful. I seek an audience with Your Greatness to bargain for Solo's life. With your wisdom, I'm sure that we can work out an arrangement which will be mutually beneficial and enable us to avoid any unpleasant confrontation.
How much are logo designs?
Greetings, Exalted One. Allow me to introduce myself. I am Luke Skywalker, Jedi Knight and friend to Captain Solo. I know that you are powerful, mighty Jabba, and that your anger with Solo must be equally powerful. I seek an audience with Your Greatness to bargain for Solo's life. With your wisdom, I'm sure that we can work out an arrangement which will be mutually beneficial and enable us to avoid any unpleasant confrontation.
View More Here
When will my website go live?
Greetings, Exalted One. Allow me to introduce myself. I am Luke Skywalker, Jedi Knight and friend to Captain Solo. I know that you are powerful, mighty Jabba, and that your anger with Solo must be equally powerful. I seek an audience with Your Greatness to bargain for Solo's life. With your wisdom, I'm sure that we can work out an arrangement which will be mutually beneficial and enable us to avoid any unpleasant confrontation.
Will I be able to upgrade down the road?
Greetings, Exalted One. Allow me to introduce myself. I am Luke Skywalker, Jedi Knight and friend to Captain Solo. I know that you are powerful, mighty Jabba, and that your anger with Solo must be equally powerful. I seek an audience with Your Greatness to bargain for Solo's life. With your wisdom, I'm sure that we can work out an arrangement which will be mutually beneficial and enable us to avoid any unpleasant confrontation.
What's the difference between the Pro plans?
Greetings, Exalted One. Allow me to introduce myself. I am Luke Skywalker, Jedi Knight and friend to Captain Solo. I know that you are powerful, mighty Jabba, and that your anger with Solo must be equally powerful. I seek an audience with Your Greatness to bargain for Solo's life. With your wisdom, I'm sure that we can work out an arrangement which will be mutually beneficial and enable us to avoid any unpleasant confrontation.
Can I cancel my membership at anytime?
Greetings, Exalted One. Allow me to introduce myself. I am Luke Skywalker, Jedi Knight and friend to Captain Solo. I know that you are powerful, mighty Jabba, and that your anger with Solo must be equally powerful. I seek an audience with Your Greatness to bargain for Solo's life. With your wisdom, I'm sure that we can work out an arrangement which will be mutually beneficial and enable us to avoid any unpleasant confrontation.

Richmond Research Institute collaborates with the following universities:

  • Aalborg University, Denmark
  • Kings College London
  • Liverpool School of Tropical Medicine
  • University of Copenhagen, Denmark
  • Pompeu Fabra University, Barcelona
  • St George's University of London
  • Toho University, Tokyo