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Our Research & Publications

We have published over 250 scientific articles in peer-reviewed journals and regularly present our research at scientific meetings.

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Cardiac Publications

Race and diurnal variability of biomarkers for diabetes and cardiovascular disease

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Confirmation of the cardiac safety of nolasiban in a randomised cohort of healthy female volunteers

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Comparing the consistency of electrocardiogram interval measurements by resting ECG versus 12-lead Holter

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A Phase 1 Study to Investigate the Effects of Cortexolone 17α-Propionate, Also Known as Clascoterone, on the QT Interval Using the Meal Effect to Demonstrate ECG Assay Sensitivity

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Effects of progesterone and estradiol on QT subintervals over the course of a menstrual cycle

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Do hERG blocking agents further increase the risk of sudden cardiac death in patients with type 1 diabetes?

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Comparison of the effects of levofloxacin on QT/QTc interval assessed in both healthy Japanese and Caucasian subjects (2011)

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Insulin at normal physiological levels does not prolong QTc interval in thorough QT studies performed in healthy volunteers (2012)

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Shortening of the QT Interval After Food Can Be Used to Demonstrate Assay Sensitivity in Thorough QT Studies (2012)

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Thorough QT study of the effect of oral moxifloxacin on QTc interval in the fed and fasted state in healthy Japanese and Caucasian subjects (2013)

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Estimation of the Power of the Food Effect on QTc to Show Assay Sensitivity (2017)

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Diurnal Profile of the QTc Interval Following Moxifloxacin Administration (2019)

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Effects of the Fluoroquinolones Moxifloxacin and Levofloxacin on the QT Subintervals: Sex Differences in Ventricular Repolarization (2019)

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The Cardiovascular Effects of a Meal: J-Tpeak and Tpeak-Tend Assessment and Further Insights Into the Physiological Effects (2019)

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Ethnicity Publications

Investigating the Effect of Intravenous APD421 (Amisulpride) and the Ethnic Differences Between Japanese and Caucasians on Cardiac Conduction

J. Täubel 1, G. Ferber 2, G. Fox , S. 3 Ferna. ndes , U. Lorch , A John Camm 1 1 4

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Cardiac Safety of Rupatadine in a Single-Ascending-Dose and Multiple-Ascending-Dose Study in Healthy Japanese Subjects

J. Taubel ¨ 1,2, G. Ferber3, S. Fernandes1, E. Santamar´ıa4, and I. Izquierdo4

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Diurnal and Racial Variance of White Blood Cell Parameters in Early Phase Clinical Trials

S. Coates 1; S Fernandes 1, D Wang 2, C Umukoro 1, D Djumanov 1, U Lorch 1, J Tiiubel 1,3

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Liver Publications

The influence of a low fat diet and hospitalisation on liver function tests in healthy Japanese and Caucasian male volunteers (2013)

U Lorch , J Singh , D Djumanov , J Täubel

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Trial Methodology Publications

Practical risk management in early phase clinical trials

Simon Coates1 & Jörg Täubel1,2 & Ulrike Lorch1

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A Box-Cox Approach to QT Interval Correction for Heart Rate

Duolao Wang, PhD 1* , Radivoj Arezina, MD 2 , Jorg Taubel, MD 2

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Three steps to writing adaptive study protocols in the early phase clinical development of new medicines

Ulrike Lorch 1*, Martin O’Kane 2 and Jorg Taubel 1

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The practical application of adaptive study design in early phase clinical trials: a retrospective analysis of time savings

U. Lorch & K. Berelowitz & C. Ozen & A. Naseem & E. Akuffo & J. Taubel

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Mason-Likar electrode configuration can confound the recognition of electrode cable interchange

Velislav N. Batchvarov, MD, PhD A. John Camm, MD, FACC, FAHA, Dilshat Djumanov, PhD Jorg Taubel, FFPM, MD

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Comparison Of Ecg Parameters Using Ge Getemed Continuous Ecg Holter And Mac-1200 Bedside Ecg

Jörg Täubel 1,2, Teresa Del Bianco 1 , Sara Fernandes 1 , Boaz Mendzelevski 3 , Dilshat Djumanov 1 , George Ferber 4

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